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Furthermore, the demonstration of cardiovascular benefits across a broad range of adiposity levels, coupled with independence from weight loss magnitude, suggests that semaglutide and perhaps other GLP-1 receptor agonists should be reconceptualized as cardiovascular disease-modifying agents rather than solely medications for glycemic control or weight loss

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319 In addition, adiponectin is an anti-inflammatory adipokine that mediates fatty acid -oxidation (FAO), glucose use, and suppression of fatty acid synthesis

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