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In contrast, SAGE-DM is not a cluster-defined or statistically derived phenotype, but a mechanistically oriented framework emphasizing the role of aging biology rather than clinical clustering

doi: 10.1111/nure.12012 Summary Keywords amino acid metabolism, diabetic kidney disease, functional foods, gut microbiota, gut-liver-kidney axis, medicine food homology, natural bioactive compounds, uremic toxins Citation Sun L, Sun G, Nan Y, Wang H, Sun Y, Shi Y, Yang Y and Wang Q (2026) Gut microbiota-liver-kidney axis in diabetic kidney disease: mechanistic insights into amino acid metabolism and nutritional intervention strategies targeting natural bioactive compounds

Longevity peptides are short-chain amino acid sequences that target specific biological systems involved in aging