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32,44 We further extend these ndings by examining a larger sample of carefully selected tissues for multiple markers of oxidative protein/DNA damage (3-NT, 8-oxo-dG), as well as functional biomarkers of inammation (3-CT) and mitochondrial superoxide production (aconitase activity)

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In this trial, 195 adult patients exposed to JARDIANCE had an eGFR between 60 and 90 mL/min/1.73 m2, 91 adult patients exposed to JARDIANCE had an eGFR between 45 and 60 mL/min/1.73 m2, and 97 patients exposed to JARDIANCE had an eGFR between 30 and 45 mL/min/1.73 m2

The International Diabetes Federation reports that over 530 million adults worldwide were living with diabetes in 2021, with this figure expected to reach over 780 million by 2045 unless the current trends are reversed