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Treat it as historical in vitro data rather than in-human evidence, the original study used cultured cells, not human subjects [16][17]

4.3 Degradation and modification of cellulose acetates by biological systems

Antioxidant Enzyme Pathways Antioxidant enzyme pathways receive enhancement through: Increased SOD activity via copper cofactor delivery Elevated catalase activity for HO breakdown Increased total glutathione levels creating stronger hydroxyl radical quenching capacity than glutathione alone Skin Regeneration and Dermal Architecture Clinical trials demonstrate profound skin rejuvenation effects that position GHK-Cu among the most effective topical and systemic anti-aging compounds

Gut 2022;71:156-62