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249,250 In vivo studies confirm mitochondrial dysfunction in high-fat diet mice, which develop neuropathy marked by reduced nerve conduction velocities and decreased IENFD

These findings demonstrate that UBQLN2 droplets catalyze -syn fibrillization and suggest that small molecules targeting fibril-catalyzing proteins such as UBQLN2 may represent a promising therapeutic approach for neurodegenerative diseases

Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses