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Stimulant laxatives (senna, bisacodyl) should be reserved for occasional breakthrough constipation rather than daily management
Erythropoietic protoporphyria , caused by ferrochelatase deficiency producing phototoxic protoporphyrin IX accumulation in erythrocytes, plasma, and skin , provides a research model for studying MC1R-mediated photoprotection in a disease context where protection from visible light-induced phototoxicity is the primary biological endpoint
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Ozempic and the Risk of nAMD A recent article in JAMA Ophthamology (June 2025) suggests that vascular changes triggered by GLP-1 activity may trigger or worsen nAMD in some patients, especially those who are older, diabetic, or already at risk for macular degeneration
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