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These include nausea, vomiting, diarrhoea, abdominal pain, constipation, and dyspepsia

Methods We searched PubMed, Embase, Scopus, Cochrane Library (CENTRAL), International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov from inception to June 25, 2025 for randomized controlled trials (RCTs) comparing venlafaxine to amitriptyline for migraine prevention

These early benefits reflect the anti-inflammatory properties of both peptides rather than structural tissue repair, which requires longer timeframes