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To mimic the postprandial glucose dynamics and exaggerated insulin secretion characteristic of PBH in mice, we developed an insulin-augmented mixed meal tolerance test
According to the American Diabetes Association Standards of Care, healthcare providers should counsel patients about expected side effects before initiating GIP/GLP-1 receptor agonist therapy to improve adherence and reduce premature discontinuation
The SURMOUNT-1 trial (N=2,539), published in the New England Journal of Medicine in 2022 (DOI: 10.1056/NEJMoa2206038), evaluated tirzepatide at 5mg, 10mg, and 15mg weekly doses versus placebo in adults with obesity or overweight