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Estrogens are also used as part of pharmacological compounds in contraceptive therapies for pre-menopausal women and hormonal replacement therapies for post-menopausal women

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Given a similar, if not superior, effectiveness for HbA 1c reduction with additional weight reduction and no intrinsic risk of hypoglycemic episodes, GLP-1RAs are recommended as the preferred first injectable glucose-lowering therapy for type 2 diabetes, even before insulin treatment