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Spermidine Like TMG, spermidine has its own suite of anti-aging benefits.39 And as a polyamine, its presence can balance against the activity of N-nicotinamide methyltransferase (NNMT), which can redirect NAM out of the salvage pathway and convert it to more harmful byproducts associated with various markers of metabolic disorders.40 41 Research points toward 15mg as a reliable dose, with lower doses performing suboptimally

The NADPH generated allows for biosynthesis of effector molecules ( Figure 1A-3 ), as well as rapid generation of ROS within phagolysosomes ( Figure 1A-2 )

Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, et al

Adding water reactivates hydrolysis pathways, and the clock starts ticking immediately upon reconstitution