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Some patients experience significant nausea, vomiting, or diarrhoea during the initial weeks, which may necessitate slower dose increases or temporary dose reductions

Missing doses reduces average drug exposure and diminishes weight loss

While murine models suggest atrial GLP-1R expression, the precise cardiac cell types expressing GLP-1R, especially in humans, are yet to be conclusively identified [33]

Patients receiving GLP-1 therapy demonstrated lower rates of advanced adenomas on surveillance colonoscopy, a finding particularly relevant given that adenoma prevention formed the evidentiary backbone for aspirins adoption in earlier prevention strategies