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Premenopausal women may experience modest menstrual cycle variations in response, with slightly enhanced sensitivity during high-estrogen phases (late follicular through ovulation)

A practical way to read the two cadences together: the weekly 5-on/2-off rhythm is a fine-grained pause aimed at short-term receptor sensitivity, while the 812-on / 4-off macro-cycle is the coarse-grained pause aimed at the whole axis

Research Applications GH Axis Research: Comprehensive dual-pathway growth hormone secretion studies

Consistent with the loss of some protein of the CI subunits, the total abundance of fully assembled CI was reduced in mitochondria from adipocyte Bmal1 KO mice (Extended Data Fig