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The inhibition of chemerin increases intracellular PUFA levels and decreases MUFA levels, leading to impaired mitochondrial respiratory chain function and CoQ10 and CIV down-regulation, resulting in more ROS generation and the induction of iron-mediated cell death (85)

ROS-induced damage to cells lining the esophagus can lead to a condition known as Barretts esophagus, a major risk factor for esophageal cancer

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Moreover, these two patients were not taking any medications at the time of the blood collection