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Both agonists cause conformational changes of the salt bridge pair E124 3.33 and R283 6.55 and the aromatic cluster W276 6.48 , F279 6.51 , H280 6.52 , and F312 7.42 , which may, in turn, lead to GHSR activation
ECs can produce and respond to vasoactive mediators, responsible for vessel relaxation or constriction
During the process of malignant transformation in normal tissues, the expression of the P-gp transporter encoded by the multidrug resistance gene 1 (MDR1) gene increases (Lu et al., 2000)
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