Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. In semaglutides extension, about two-thirds returned within one year. The pattern reflects removal of appetite suppression after major weight loss
Additionally, significant AEs of pancreatitis acute ( n = 61, ROR 5.83, 95% CI 4.527.50), pancreatic carcinoma ( n = 49, ROR 1.73, 95% CI 1.312.30), obstructive pancreatitis ( n = 16, ROR 31.13, 95% CI 18.8151.51), and pancreatic carcinoma metastatic ( n = 12, ROR 9.95, 95% CI 5.6217.61) were also observed
Fatigue isnt listed as the most common side effect of semaglutide, but its something some patients do report, especially in the early stages of treatment
If you observe any of the following warning signs, immediately discontinue use and contact your healthcare provider: visible particles or sediment that don't dissolve with gentle swirling, cloudiness or haziness in the solution, any pink, yellow, brown or other discoloration, or an unusual odor when opening the vial
