orlistat glp 1 Obesity pharmacotherapy from the @TheAACE diabetes algorithm: GLP‑1/GIP and GLP‑1 RAs produce ~10–20% weight loss with A1c reduction, while older agents like phentermine, orlistat, and naltrexone/bupropion have less efficacy and safety trade‑offs Glucagon-like Peptide 1 Receptor Agonists
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