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GLP-1RAs also exert anti-arrhythmic effects via reducing calcium leak from the sarcoplasmic reticulum in ventricular arrhythmia, which has the potential to decrease phosphorylation of the type 2 ryanodine receptor (RyR2) and alleviate the activity of CaMK-II [77]

This may be due to the sex hormones oestrogen and progesterone, which can alter the guts sensitivity

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Understanding those effects could help guide how we approach prevention and treatment of AFib in the future. This single-center, retrospective study looked at 13,034 patients who initiated GLP-1-RA therapy between January 2020 and May 2024