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I've used up ampoules that are long out of date and have been subjected to fluctuating heat (terrible for wine!) due to being in my car, etc, and haven't noticed any difference

Other countries, other specialists, can often allow for more regular injections on a patient-by-patient basis

Because responses differ from person to person, the safest approach is to follow the suggested use on your product and work with a qualified healthcare provider to decide what duration fits your situation