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EXAMPLE 15: EFFECT OF THE MOLAR SUBSTITUTION DEGREE OF HP-B-CD ON THE PHYSICAL AND CHEMICAL STABILITY OF CAGRILINTIDE AND SEMAGLUTIDE COFORMULATIONS This example shows the effect of the molar substitution of HP-B-CD on the formation of sub-visible particles, HMWP level and chemical purity of semaglutide in otherwise identical, citrate-buffered cagrilintide and semaglutide co-formulations

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With the expanding use of GLP-1 RAs in both diabetic and non-diabetic populations, clinicians should remain vigilant for pancreatic structural abnormalities and maintain a high index of suspicion in patients developing new gastrointestinal symptoms while on therapy