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Weve been very interested in providing some policyrelevant evidence about what it would take to save money in the long run. Achieving cost neutrality would require the long-term healthcare savings to completely offset the cost of the drugs

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While Ada1 HFD showed the typical HFD conformation but with a very long loop L2 and a shorter 3 helix, HFD of Taf4 showed an atypical conformation with 3 helix assuming a different orientation extending outside (Figure S6B i-iii)

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