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Tissue Inhibitor of Metalloproteinase (TIMP) Interactions The balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), determines net proteolytic activity in tissues

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Canagliflozin ameliorates ulcerative colitis via regulation of TLR4/MAPK/NF-B and Nrf2/PPAR-/SIRT1 signaling pathways