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The variability in clinical response among patients with BD has been increasingly attributed to genetic factors, with specific polymorphisms in genes such as GSK3B, NTRK2, ADCY1, FAM177A1, GRAMD1B, and ZNF804A showing strong associations with treatment outcomes

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Wong J., Chen Y., Gan Y.H

While no formal clinical trials have established optimal combined dosing, synthesis of available research and community experience provides practical guidance