Clinical research demonstrates reductions in adipocyte size of 30-40%, with preferential targeting of visceral adipose tissue
Unsurprisingly, this has made Asprey suspicious of regulation
Likewise, many cuproproteins with redox, or redox-with-transport functions (mono-, di-, tetranuclear cupredoxins nitrite reductase, laccase, Cu, Zn-SOD1, amine oxidase CuAO, galactose oxidase, hemocyanin, tyrosinase, catechol oxidase, COX, N 2 O reductase, menaquinol NO reductase et cetera) [47], copper-transporting ATPases (Cu-ATPases, ATP7A and ATP7B) [124,125,126], divalent metal transporter DMT1 [127], copper transporters and chaperons Ctr1, Ctr2, Atox1 and CCS [128, 129], diverse group of bacterial periplasmic copper binding proteins (CopC) [130] are known
Polyphenols, nerve growth factor, brain-derived neurotrophic factor, and the brain, in Bioactive nutraceuticals and dietary supplements in neurological and brain disease (Elsevier), 6571