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This feedback loopfibrosis enabling SIBO, and SIBO amplifying fibrosistypifies the fibro-inflammatory circuit that underlies gastrointestinal involvement in SSc

Furthermore, it encourages the consideration of this combination in those with an ACR of 330 mg/mmol (depending on individual drug licence indications, noting that not all SGLT2 inhibitors are currently licensed for this use)

Additional mechanistic references explore molecular frameworks related to lipid metabolismassociated signaling pathways and peptide-mediated molecular interactions evaluated through analytical and observational research approaches

[sources 16] SLC1A1 is excitatory amino acid transporter 3 (EAAT3), a glutamate transporter located in neurons, SLC22A3 is an extraneuronal monoamine transporter that is present in astrocytes, and SLC22A5 is a high-affinity carnitine transporter