Many commenters stated that this structure creates a potential conflict of interest and could limit transparency, competition, and public trust
in: Journal of Molecular Biology , 267 (1997)4, 1039-1052) Previous studies of model peptides have also shown that salt bridges spaced at i,i +4 along the peptide chain are more stabilizing than those spaced at i,i +3, with a preference for the order acid-base rather than base-acid from the N- to the C- terminus
Response: We thank the commenters for providing their concerns regarding survey fatigue and low response rates, and the suggestion to integrate the Information Transfer PRO-PM with the OAS CAHPS survey to reduce the number of surveys a patient could receive regarding their episode of care
However, oral semaglutide has different bioavailability and absorption characteristics, which is why most people on injectable GLP-1 therapy are working with products that need the fridge