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Primary bile acids (BAs) derived by Cholesterol are regulated by the nuclear FXR and the TGR5 and convert into secondary bile acids through 7-dehydroxylation reaction, which includes deoxycholic acid and lithocholic acid [194, 195]

Metabolic syndrome-associated osteoarthritis

The FDA-approved prescribing information does not list protein supplements as incompatible with the medication, and no pharmacokinetic interactions between tirzepatide and dietary protein have been documented

Heparanase is also overexpressed in some malignant tumors and is activated in sepsis, causing partial degradation of the glycocalyx, which further exacerbates the loss of glycocalyx components (65)