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Hepatic lipid assays: Ex vivo hepatic tissue studies and hepatocyte cell-line work have documented retatrutide's effect on markers associated with non-alcoholic fatty liver models, including lipid droplet accumulation and markers of hepatic lipid flux

EAT inflammation may be also considered an adaptive response of adipose tissue to the effects of glucagon-like peptide-1 receptor (GLP-1Rs) and glucose-dependent insulinotropic polypeptide (GIP) analogs

We observed co-localization of a phosphorylated NPM1 (T199), a protein that shuttles between the nucleolus and the nucleus 28,29 , and -H2AX, a histone protein that binds to DNA damage sites 30 (Fig