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18 Long-acting GLP-1 RAs include liraglutide, dulaglutide, exenatide XR, and semaglutide

Caution is also warranted in patients with a history of pancreatitis

It is important to note that: Most clinical trials have follow-up periods of 25 years, which may not capture very long-term cancer development Patients with type 2 diabetes and obesity have baseline elevated cancer risks due to metabolic factors Post-marketing surveillance continues to monitor for rare or delayed adverse events The Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA) continue to review safety data as part of ongoing pharmacovigilance activities, and no major cancer-related safety signals have emerged that would warrant withdrawal or significant restriction of these medicines

In recent years, glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, liraglutide, and exenatide, have emerged as highly effective agents for inducing substantial weight loss [3]