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Since the majority of present research on UPS is preclinical, more work must be done to confirm its precise mechanism in human illnesses

Interestingly the ABC transporters are often upregulated in chemoresistant cancers, since they efficiently excrete chemotherapeutic drugs such as doxorubicin, taxane- and platinum-based drugs from cancer cells

Impairment of endothelium-dependent relaxation of rabbit aortas by cigarette smoke extract: role of free radicals and attenuation by captopril