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It works by simultaneously activating the glucose-dependent insulinotropic polypeptide receptor (GIP-R) and glucagon-like peptide-1 receptor (GLP-1R), which results in increased insulin release, decreased glucagon secretion, reduced hunger, delayed gastric emptying, and significant weight loss

[DOI] [PubMed] [Google Scholar] 66.Pan S., Yang J., Ji S., Li T., Gao S., Sun C., Xu H