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It is influenced by C-19 acute phase severity and the use of analgesics, genetic predisposition to migraine due to trigeminovascular system activation, and systemic immune response at viral infection (55)

Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma

Many of these factors undergo changes during viral infections and may influence the redox state of the cell

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