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Post-Exertional Malaise (PEM) and "Crashes": By keeping the "histamine bucket" from overflowing, the formula helps mitigate the massive inflammatory cascades that trigger debilitating, multi-day crashes after minor physical or cognitive exertion

10.1056/NEJM199704103361518 155 SahebnasaghA.AvanR.MonajatiM.HashemiJ.HabtemariamS.NegintajiS.et al (2022)

Regarding FMV assessments, we proposed manufacturers conduct periodic updates of any FMV analyses for service arrangements that are ongoing, at a frequency no less than the renewal frequency of the agreement (that is, annually for annual renewals)