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While the exact timeline varies for everyone, many individuals with a genuine B12 deficiency begin to experience noticeable improvements in their energy levels within a few days to a week after their first injection

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Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis

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Numb the skin A person or their caregiver can apply a numbing cream a few minutes before the injection to reduce the sensitivity of the skin

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Multiple doses are common at the start of treatment, with monthly maintenance injections afterward

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