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Semaglutide targets appetite and metabolism rather than removing fat

GH-class peptides like CJC-1295/ipamorelin and tesamorelin promote lipolysis through hormone-sensitive lipase activation a mechanism that depends on adequate cellular energy machinery to oxidize the mobilized fatty acids

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Nevertheless, many of them also present insulin resistance and inflammatory cytokine secretion, so it is difficult to determine the exact role of each component in the cardiovascular outcome