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Concurrently, serum IL-1 levels dropped significantly, and caspase-1 and IL-1 expression decreased by over 80% ( Limitations: Although GGC supplementation replicated key phenotypes in vivo , the study did not include in vivo blocking verification for GGC generation/transport or the NLRP3 module

David Sinclair discusses the current state of research on nicotinamide mononucleotide