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So far preferential activation of GIPR activation, combined with less activation of GLP1R and even less activation of GR appear to have produced the most effective combination, as shown by Retatrutide, although whether this mixture is indeed the optimal is still an open question

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doi: 10.3389/fimmu.2021.660342 Received 29 January 2021 Accepted 26 March 2021 Published 15 April 2021 Volume 12 - 2021 Edited by Agnieszka Paradowska-Gorycka, Rheumatology and Rehabilitation, Poland Reviewed by Chiara DAngelo, University of Studies G