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Mechanistically, this variant disrupts SP1 transcription factor binding to the JMJD3 promoter, reducing its expression in vascular smooth muscle cells (SMCs)

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Then we estimated energy use from the components of the Na + /K + -ATPase rate equation (calculated from the sum of neuron and astrocyte Na + /K + pump ATP consumption flux in mM concentration per second with the volume of 17.8 m 3 and the literature estimate of ionic gradients sharing 31% of total energy use) and compared it to the literature estimates ( Presentation 1: Supplementary Table S1