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Wherfe insurance coverage for GLP-1 agonists lacks, alternative medications can suffice for weight maintenance

Recent Trends in GLP-1 Use and Spending in Medicare Ahead of the Trump administrations planned expansion of Medicare coverage for GLP-1s to treat obesity through temporary models and the availability of Medicares negotiated price for certain GLP-1 products beginning in 2027, new data from the Centers for Medicare & Medicaid Services (CMS) shows that use and spending for these drugs under Medicare has grown substantially in recent years, reflecting their demonstrated effectiveness at treating type 2 diabetes and other conditions

Multi-targeted mechanism: Simultaneously modulates three hormone pathways, potentially offering broader metabolic benefits (weight, glycemic control, liver fat) compared to dual/mono-agonists

They have free radical-scavenging and anti-inflammatory effects, and some are precursors of vitamin A