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For major depression, the maximum daily dose is 450mg, while for seasonal affective disorder (SAD) prevention, the maximum is 300mg

This is particularly significant given that 52% of study participants indicated that they did not intend to stay on GLP-1s for the long term, and few received supplement recommendations from their healthcare professionals when starting treatment, she added

Further clinical studies are essential to define its full scope of benefits better and confirm its therapeutic potential across diverse populations

Side effects improve significantly over time Second Natures research showed that side effects decrease substantially as the body adjusts to the medication: 3 Nausea dropped from 31.5% to 3.1% (semaglutide) and 27.8% to 10.5% (tirzepatide) by month 12 Fatigue dropped from 24.6% to 3.1% (semaglutide) and 21.5% to 8.1% (tirzepatide) by month 12 The proportion reporting no side effects increased significantly in both groups Hair loss: what the research shows Hair loss is often reported as a concern with weight-loss medications