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+ = observed, - = not observed, A = EMA product information ( Human An earlier review on pharmacotherapy for gestational diabetes reported no human data on the safety of GLP-1 agonists during pregnancy and concluded that these drugs cannot be recommended in pregnancy ( th week of gestation ( th week of gestation was identified ( ex vivo equilibrium perfusion experiment of human placentas with exenatide that measured a fetal-to-maternal peptide concentration ratio of 0.017 meaning negligible placental passage ( SGLT2 inhibitors during pregnancy Animal None of the SGLT2 inhibitors showed developmental toxicity when a dose not resulting in maternal toxicity was administered during the interval coinciding with the first trimester period of organogenesis except for canagliflozin, where ossification delays of the metatarsal bones were seen ( Table 2 )