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Phase II blood plasma samples were analyzed in batch following study completion

Four of the genes ( CHAMP1, GFAP, POGZ TUBB3 ) are reported in the literature as associated predominately with syndromes, meaning a set of specific disease manifestations especially neurodevelopmental disease with or without congenital malformations and dysmorphic features

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They improved renal fibrosis and inflammation by increasing levels of SCFAs and IAld, decreasing levels of uremic toxins, inhibiting TGF-/Smad signaling pathway, as well as inflammatory factors, reducing tryptophan transport and indole synthesis