And remember, when you dont have enough patients to pass that cost on to, the price per person will be significantly higher, although the overall cost to the system or health system or the government is not significant because there arent that many patients
Women of childbearing potential should use effective contraception and discontinue treatment before planned pregnancy (for semaglutide, at least 2 months before conception)
For example, one extensive review of semaglutides safety discusses the incidence of pancreatitis in study participants, as well as the potential link between GLP-1 RAs and pancreatic cancer.16 Its a sensible thing to study considering these drugs effect on the pancreas, and cases of pancreatitis were present in several studies, but researchers note that the incidence isnt meaningfully higher than that of the general population outside the study group
Recent studies reported that GLP-1 increases the phosphorylation of AMPK in hepatocytes and reverses hepatic steatosis by stimulating fatty acid oxidation [8,31,32]
