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But clinical trial data from SURMOUNT and SURPASS programs did not show increased rates of depression or anxiety

In physical dependence assay (isoniazid challenge assessed at 6, 14, 42 and 72 h after conditioning medication), when compared to diazepam non-conditioned healthy mice, in diazepam conditioned mice residual anticonvulsive activity was not present already at the earliest post-conditioning interval (i.e., not different latency to isoniazid-convulsions), whereas shorter preconvulsive latencies (as physical dependence/withdrawal hallmark) were noted in diazepam conditioned mice following isoniazid challenge at 42 h and at 72 h after end of conditioning treatment

It is recommended to store the vial in a dry place protected from light

doi: 10.3389/fnagi.2014.00184 [DOI] [PMC free article] [PubMed] [Google Scholar] 101