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Research on curcumin and endometriosis suggests it can help: Reduce inflammatory pain signaling Lower pro-inflammatory cytokines Support immune regulation without the gut irritation associated with long-term NSAID use One review 6 found that curcumin helped support endometriosis by reducing inflammation and oxidative stress while also influencing processes involved in lesion growth, adhesion, and abnormal blood vessel formation

Acknowledgments We thank Giorgos Kastellakis for helpful comments on the manuscript

(Frontiers in Pharmacology, 2022) reports a half-life under 30 minutes after IM or IV administration in rodent and dog models, which is why split-dose schedules appear in the literature

On the other hand, HMOX1 expression in SMARCA4 knockout cell lines was higher than that in SMARCA4-proficient cells 23