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Participants using tirzepatide 15 mg lost a mean of 22.5% of body weight versus 2.4% in the placebo group over 72 weeks - the largest weight reduction ever documented in a Phase 3 placebo-controlled trial for a pharmacological weight management agent at the time of publication, a figure that represented a significant outcome in the drug class at the time of publication

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That trial showed that there were improved glucose outcomes and a trend toward improved maternal and fetal outcomes as well

This requires careful nutritional assessment and monitoring, especially in younger adults or those with a history of eating disorders