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2025 demonstrates that chronic GCGR agonism downregulates hepatocyte PDE4B/4D phosphodiesterases, producing sustained cAMP-PKA signaling that preserves resting energy expenditure against the adaptive decline of weight loss

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We note that all comments requesting the reassignment of CPT code 52282 to APC 5376 were related to a device that has not received FDA approval or any exceptions such as an Investigational Device Exemptions (IDE) or PMA/510K Exemptions, and so those comments are out of the scope for this final rule with comment period