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Other synergistic therapeutic strategies may involve combining TOPI inhibitor-based ADCs with androgen receptor inhibitors (ARi) or HIF-1\(\alpha\) inhibitors

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Patients experiencing severe or persistent vomiting or diarrhoea should seek medical advice promptly, as dehydration may increase the risk of acute kidney injury

Acetaminophen inhibits the synthesis of prostaglandin (PG) E2, PGF2, and thromboxane B2 by lipopolysaccharide (LPS)-stimulated microglia, yet has no effect on the levels of pro-inflammatory mediators such as tumor necrosis factor (TNF)- and NO [19,20]