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A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

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It would be in a really small niche circuit, whereas now it is advertised and promoted, and companies are shouting about it, which I personally dont agree with

But often, bacteria that is the product of the waste of warm blooded animals is a culprit of infection and disease