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Ongoing use may be needed to maintain weight loss, as stopping the medication often leads to gradual weight regain, especially in the absence of lifestyle changes

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Ubidecarenone enhances succinate-dependent and glycerol-3-phosphate-dependent ROS generation, mitochondrial membrane depolarization, and regulated cell death Impairments to the mitochondrial ETC, in particular the loss of efficiency in electron transfer from Complex III or mGPDH to oxygen (as reported above), can result in electron leakage and ROS generation 10

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