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Custer said overweight and obese patients with Type 2 diabetes are typically more resistant to weight loss than those without the condition

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Reformulation Strategies Under Investigation The original MK-677 formulation (oral capsule, immediate release) presents known limitations: once-daily dosing produces supraphysiologic GH peaks in the first 2-3 hours followed by gradual decline, and systemic exposure drives appetite and glucose effects 1